Ryanodine and dihydropyridine receptor binding in ventricular cardiac muscle of fish with different temperature preferences.
Identifieur interne : 000A42 ( Main/Exploration ); précédent : 000A41; suivant : 000A43Ryanodine and dihydropyridine receptor binding in ventricular cardiac muscle of fish with different temperature preferences.
Auteurs : V. Tiitu [Finlande] ; M. VornanenSource :
- Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology [ 0174-1578 ] ; 2003.
Descripteurs français
- KwdFr :
- Acclimatation (MeSH), Animaux (MeSH), Basse température (MeSH), Canal de libération du calcium du récepteur à la ryanodine (métabolisme), Canaux calciques de type L (métabolisme), Carpes (poisson) (MeSH), Environnement (MeSH), Myocarde (métabolisme), Oncorhynchus mykiss (MeSH), Poissons (métabolisme), Rats (MeSH), Ryanodine (métabolisme), Spécificité d'espèce (MeSH), Température (MeSH), Ventricules cardiaques (MeSH).
- MESH :
English descriptors
- KwdEn :
- Acclimatization (MeSH), Animals (MeSH), Calcium Channels, L-Type (metabolism), Carps (MeSH), Cold Temperature (MeSH), Environment (MeSH), Fishes (metabolism), Heart Ventricles (MeSH), Myocardium (metabolism), Oncorhynchus mykiss (MeSH), Rats (MeSH), Ryanodine (metabolism), Ryanodine Receptor Calcium Release Channel (metabolism), Species Specificity (MeSH), Temperature (MeSH).
- MESH :
- chemical , metabolism : Calcium Channels, L-Type, Ryanodine, Ryanodine Receptor Calcium Release Channel.
- metabolism : Fishes, Myocardium.
- Acclimatization, Animals, Carps, Cold Temperature, Environment, Heart Ventricles, Oncorhynchus mykiss, Rats, Species Specificity, Temperature.
Abstract
Ca(2+)-induced Ca2+ release (CICR) mechanism of cardiac excitation-contraction (e-c) coupling is dependent on the close apposition between the sarcolemmal dihydropyridine receptors (DHPR) and the sarcoplasmic reticulum (SR) ryanodine receptors (RyR). In particular, high RyR/DHPR ratio is considered to reflect strong dependence on SR Ca2+ stores for the intracellular Ca2+ transient. To indirectly evaluate the significance of CICR in fish hearts, densities of cardiac DHPRs and RyRs were compared in ventricular homogenates of three fish species (burbot, rainbow trout, and crucian carp) and adult rat by [3H] PN200-110 and [3H] ryanodine binding. The density of RyRs was significantly (P<0.05) higher in the adult rat (124+/-10 channels/microm3 myocyte volume) than in any of the fish species. Among the fish species, cold-acclimated (4 degrees C) trout had more RyRs than burbot, and crucian carp. The density of DHPRs was highest in the trout heart. RyR/DHPR ratio was significantly (P<0.05) higher in rat (4.1+/-0.5) than in the fish hearts (varying from 0.97+/-0.16 to 1.91+/-0.49) suggesting that "mammalian type" CICR is less important during e-c coupling in fish ventricular myocytes. In rainbow trout, acclimation to cold did not affect the RyR/DHPR ratio, while in crucian carp it was depressed in cold-acclimated animals (4 degrees C; 0.97+/-0.16) when compared to warm-acclimated fish (23 degrees C; 1.91+/-0.49). Although RyR/DHPR ratios were relatively low in fish hearts, there was a close correlation (r2=0.78) between the RyR/DHPR ratio and the magnitude of the Ry-sensitive component of contraction in ventricular muscle among the fish species examined in this study.
DOI: 10.1007/s00360-003-0334-z
PubMed: 12664089
Affiliations:
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Tiitu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Joensuu, PO Box 111, 80101 Joensuu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Biology, University of Joensuu, PO Box 111, 80101 Joensuu</wicri:regionArea><wicri:noRegion>80101 Joensuu</wicri:noRegion></affiliation></author><author><name sortKey="Vornanen, M" sort="Vornanen, M" uniqKey="Vornanen M" first="M" last="Vornanen">M. Vornanen</name></author></analytic><series><title level="j">Journal of comparative physiology. 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In particular, high RyR/DHPR ratio is considered to reflect strong dependence on SR Ca2+ stores for the intracellular Ca2+ transient. To indirectly evaluate the significance of CICR in fish hearts, densities of cardiac DHPRs and RyRs were compared in ventricular homogenates of three fish species (burbot, rainbow trout, and crucian carp) and adult rat by [3H] PN200-110 and [3H] ryanodine binding. The density of RyRs was significantly (P<0.05) higher in the adult rat (124+/-10 channels/microm3 myocyte volume) than in any of the fish species. Among the fish species, cold-acclimated (4 degrees C) trout had more RyRs than burbot, and crucian carp. The density of DHPRs was highest in the trout heart. RyR/DHPR ratio was significantly (P<0.05) higher in rat (4.1+/-0.5) than in the fish hearts (varying from 0.97+/-0.16 to 1.91+/-0.49) suggesting that "mammalian type" CICR is less important during e-c coupling in fish ventricular myocytes. In rainbow trout, acclimation to cold did not affect the RyR/DHPR ratio, while in crucian carp it was depressed in cold-acclimated animals (4 degrees C; 0.97+/-0.16) when compared to warm-acclimated fish (23 degrees C; 1.91+/-0.49). Although RyR/DHPR ratios were relatively low in fish hearts, there was a close correlation (r2=0.78) between the RyR/DHPR ratio and the magnitude of the Ry-sensitive component of contraction in ventricular muscle among the fish species examined in this study.</div></front></TEI><affiliations><list><country><li>Finlande</li></country></list><tree><noCountry><name sortKey="Vornanen, M" sort="Vornanen, M" uniqKey="Vornanen M" first="M" last="Vornanen">M. Vornanen</name></noCountry><country name="Finlande"><noRegion><name sortKey="Tiitu, V" sort="Tiitu, V" uniqKey="Tiitu V" first="V" last="Tiitu">V. Tiitu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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